'Biosensors' on Four Feet Detect Animals Infected With Bird Flu

mouse earns a water reward for choosing the odor of samples of feces infected with avian flu over a feces sample from ducks that were not infected.

---

Blood hounds, cadaver dogs, and other canines who serve humanity may soon have a new partner ― disease detector dogs ― thanks to an unusual experiment in which scientists trained mice to identify feces of ducks infected with bird influenza. Migrating ducks, geese, and other birds can carry and spread flu viruses over wide geographic areas, where the viruses may possibly spread to other species.

Reported in Boston at the 240th National Meeting of the American Chemical Society (ACS), the proof-of-concept study may pave the way for development of biosensors-on-four-feet that warn of infection with influenza and other diseases.

"Based on our results, we believe dogs, as well as mice, could be trained to identify a variety of diseases and health conditions," said U.S. Department of Agriculture scientist Bruce A. Kimball, Ph.D., who presented the study results. The study was among nearly 8,000 scientific reports scheduled for presentation at the ACS meeting, one of the largest scientific gatherings of 2010.

"In fact, we envision two broad, real-world applications of our findings," Kimball added. "First, we anticipate use of trained disease-detector dogs to screen feces, soil, or other environmental samples to provide us with an early warning about the emergence and spread of flu viruses. Second, we can identify the specific odor molecules that mice are sensing and develop laboratory instruments and in-the-field detectors to detect them."

Kimball cited the likelihood that a suite of chemicals, rather than a single compound, are responsible for producing the difference in fecal odor between healthy and infected ducks. His team is investigating the use of instruments in detecting these so-called volatile, or gaseous, metabolites in animal feces. Once accomplished, they can use statistical techniques to sift through the data to determine the pattern of volatiles that indicate the presence of infection.

Kimball and colleagues from the Monell Chemical Senses Center trained inbred mice to navigate a maze and zero in on infected duck feces. The mice got a reward of water every time they correctly identified the infected sample and no reward when they zeroed in on feces from healthy ducks. Eventually, the mice became experts at identifying feces from infected ducks.

Magnetism's Subatomic Roots: Study of High-Tech Materials Helps Explain Everyday Phenomenon

A new theoretical physics model helps define the subatomic origins of ferromagnetism -- the everyday "magnetism" of compass needles and refrigerator magnets.

---

The modern world -- with its ubiquitous electronic devices and electrical power -- can trace its lineage directly to the discovery, less than two centuries ago, of the link between electricity and magnetism. But while engineers have harnessed electromagnetic forces on a global scale, physicists still struggle to describe the dance between electrons that creates magnetic fields.

Two theoretical physicists from Rice University are reporting initial success in that area in a new paper in the Proceedings of the National Academy of Sciences. Their new conceptual model, which was created to learn more about the quantum quirks of high-temperature superconductors and other high-tech materials, has also proven useful in describing the origins of ferromagnetism -- the everyday "magnetism" of compass needles and refrigerator magnets.

"As a theorist, you strive to have exact solutions, and even though our new model is purely theoretical, it does produce results that match what's observed in the real world," said Rice physicist Qimiao Si, the lead author of the paper. "In that sense, it is reassuring to have designed a model system in which ferromagnetism is allowed."

Ferromagnets are what most people think of as magnets. They're the permanently magnetic materials that keep notes stuck to refrigerators the world over. Scientists have long understood the large-scale workings of ferromagnets, which can be described theoretically from a coarse-grained perspective. But at a deeper, fine-grained level -- down at the scale of atoms and electrons -- the origins of ferromagnetism remain fuzzy.

"When we started on this project, we were aware of the surprising lack of theoretical progress that had been made on metallic ferromagnetism," Si said. "Even a seemingly simple question, like why an everyday refrigerator magnet forms out of electrons that interact with each other, has no rigorous answer."

Si and graduate student Seiji Yamamoto's interest in the foundations of ferromagnetism stemmed from the study of materials that were far from ordinary.

Si's specialty is an area of condensed matter physics that grew out of the discovery more than 20 years ago of high-temperature superconductivity. In 2001, Si offered a new theory to explain the behavior of the class of materials that includes high-temperature superconductors. This class of materials -- known as "quantum correlated matter" -- also includes more than 10 known types of ferromagnetic composites.

Si's 2001 theory and his subsequent work have aimed to explain the experimentally observed behavior of quantum-correlated materials based upon the strangely correlated interplay between electrons that goes on inside them. In particular, he focuses on the correlated electron effect that occur as the materials approach a "quantum critical point," a tipping point that's the quantum equivalent of the abrupt solid-to-liquid change that occurs when ice melts.

The quantum critical point that plays a key role in high-temperature superconductivity is the tipping point that marks a shift to antiferromagnetism, a magnetic state that has markedly different subatomic characteristics from ferromagnetism. Because of the key role in high-temperature superconductivity, most studies in the field have focused on antiferromagnetism. In contrast, ferromagnetism -- the more familiar, everyday form of magnetism -- has received much less attention theoretically in quantum-correlated materials.

"So our initial theoretical question was, 'What would happen, in terms of correlated electron effects, when a ferromagnetic material moves through one of these quantum tipping points?" said Yamamoto, who is now a postdoctoral researcher at the National High Magnetic Field Laboratory in Tallahassee, Fla..

To carry out this thought experiment, Si and Yamamoto created a model system that idealizes what exists in nature. Their jumping off point was a well-studied phenomenon known as the Kondo effect -- which also has its roots in quantum magnetic effects. Based on what they knew of this effect, they created a model of a "Kondo lattice," a fine-grained mesh of electrons that behaved like those that had been observed in Kondo studies of real-world materials.

Si and Yamamoto were able to use the model to provide a rigorous answer about the fine-grained origins of metallic ferromagnetism. Furthermore, the ferromagnetic state that was predicted by the model turned out to have quantum properties that closely resemble those observed experimentally in heavy fermion ferromagnets.

"The model is useful because it allows us to predict how real-world materials might behave under a specific set of circumstances," Yamamoto said. "And, in fact, we have been able to use it to explain experimental observations on heavy fermion metals, including both the antiferromagnets as well as the less well understood ferromagnetic materials."

Miniature Auto Differential Helps Tiny Aerial Robots Stay Aloft

Microrobots could be used for search and rescue, agriculture, environmental monitoringEngineers at Harvard University have created a millionth-scale automobile differential to govern the flight of minuscule aerial robots that could someday be used to probe environmental hazards, forest fires, and other places too perilous for people.

Their new approach is the first to passively balance the aerodynamic forces encountered by these miniature flying devices, letting their wings flap asymmetrically in response to gusts of wind, wing damage, and other real-world impediments.

"The drivetrain for an aerial microrobot shares many characteristics with a two-wheel-drive automobile," says lead author Pratheev S. Sreetharan, a graduate student in Harvard's School of Engineering and Applied Sciences. "Both deliver power from a single source to a pair of wheels or wings. But our PARITy differential generates torques up to 10 million times smaller than in a car, is 5 millimeters long, and weighs about one-hundredth of a gram -- a millionth the mass of an automobile differential."

High-performance aerial microrobots, such as those the Harvard scientists describe in the Journal of Mechanical Design, could ultimately be used to investigate areas deemed too dangerous for people. Scientists at institutions including the University of California, Berkeley, University of Delaware, University of Tokyo, and Delft University of Technology in the Netherlands are exploring aerial microrobots as cheap, disposable tools that might someday be deployed in search and rescue operations, agriculture, environmental monitoring, and exploration of hazardous environments.

To fly successfully through unpredictable environments, aerial microrobots -- like insects, nature's nimblest fliers -- have to negotiate conditions that change second-by-second. Insects usually accomplish this by flapping their wings in unison, a process whose kinematic and aerodynamic basis remains poorly understood.

Sreetharan and his co-author, Harvard engineering professor Robert J. Wood, recognized that an aerial microrobot based on an insect need not contain complex electronic feedback loops to precisely control wing position.

"We're not interested so much in the position of the wings as the torque they generate," says Wood, an associate professor of electrical engineering at Harvard. "Our design uses 'mechanical intelligence' to determine the correct wing speed and amplitude to balance the other forces affecting the robot. It can slow down or speed up automatically to correct imbalances."

Sreetharan and Wood found that even when a significant part of an aerial microrobot's wing was removed, the self-correction engendered by their PARITy (Passive Aeromechanical Regulation of Imbalanced Torques) drivetrain allowed the device to remain balanced in flight. Smaller wings simply flapped harder to keep up with the torque generated by an intact wing, reaching speeds of up to 6,600 beats per minute.

The Harvard engineers say their passive approach to regulating the forces generated in flight is preferable to a more active approach involving electronic sensors and computation, which would add weight and complexity to devices intended to remain as small as lightweight as possible. Current-generation aerial microrobots are about the size and weight of many insects, and even make a similar buzzing sound when flying.

"We suspect that similar passive mechanisms exist in nature, in actual insects," Sreetharan says. "We take our inspiration from biology, and from the elegant simplicity that has evolved in so many natural systems."

Sreetharan and Wood's work was funded by the National Science Foundation.

---

Story Source:

The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Harvard University, via EurekAlert!, a service of AAAS.

Ants Take on Goliath Role in Protecting Trees in the Savanna from Elephants

Ants are not out of their weight class when defending trees from the appetite of nature's heavyweight, the African elephant, a new University of Florida study finds.

Columns of angered ants will crawl up into elephant trunks to repel the ravenous beasts from devouring tree cover throughout drought-plagued East African savannas, playing a potentially important role in regulating carbon sequestration in these ecosystems, said Todd Palmer, a UF biology professor and co-author of a paper being published in the journal Current Biology.

"It really is a David and Goliath story, where these little ants are up against these huge herbivores, protecting trees and having a major impact on the ecosystems in which they live," Palmer said. "Swarming groups of ants that weigh about 5 milligrams each can and do protect trees from animals that are about a billion times more massive."

The mixture of trees and grasses that make up savanna ecosystems are traditionally thought to be regulated by rainfall, soil nutrients, plant-eating herbivores and fire, he said.

"Our results suggest that plant defense should be added to the list," he said. "These ants play a central role in preventing animals that want to eat trees from doing extensive damage to those trees."

While conducting research in the central highlands of Kenya, where hungry elephants have destroyed much of the tree cover, Palmer said he and his colleague and former UF post-doctoral student, Jacob Goheen, now a University of Wyoming zoology, physiology and botany professor, noticed that elephants rarely ate a widespread tree species known as Acacia drepanolobium where guardian ants aggressively swarm anything that touches the trees. But they would feed on other trees that did not harbor these ants.

The researchers decided to test whether these tiny ants were repelling the world's largest land mammal by serving as bodyguards for the tree in exchange for shelter and the food it supplied in the form of a sugary nectar solution. So they offered elephants at a wildlife orphanage a choice between these "ant plant" trees, with and without ants on the branches, and their favorite species of tree, the Acacia mellifera, to which the researchers added ants to some of its otherwise antless branches.

"We found the elephants like to eat the "ant plant" trees just as much as they like to eat their favorite tree species, and that when either tree species had ants on them, the elephants avoided those trees like a kid avoids broccoli," he Palmer said.

Also, the researchers removed ants from "ant trees" out in the field to see if elephants would attack them undefended, and a year later found much more damage than on trees with ants. Satellite images between 2003 and 2008 confirmed the ants were having a widespread, long-term effect throughout the savanna, he said.

The ants did not seem to annoy tree-feeding giraffes, who used their long tongues to swipe away them away from their short snouts, in marked contrast to the long nose or trunk on an elephant, Palmer said. The inside of an elephant's trunk is tender and highly sensitive to thousands of biting ants swarming up into it, he said.

"An elephant's trunk is a truly remarkable organ, but also appears to be their Achille's heel when it comes to squaring off with an angry ant colony," he said.

Because it appears that smell alerts elephants to avoid trees that are occupied by ants, it raises the question of whether ant odors might be applied to crops to deter elephants from feeding on them, just as DEET helps repel mosquitoes from people, he said.

"A big issue in east Africa is elephants damaging crops, which is one reason elephants have been harassed and sometimes killed," he said. "There's been a lot of interest in the conservation world about how to minimize the conflict elephants have with humans and particularly how to keep elephants from raiding agricultural fields."

One predicted outcome of global warming is more frequent and intense droughts, which will force desperate elephants to eat everything they can to survive, Palmer said "With more droughts, the extent to which elephants destroy and remove trees may increase and potentially shift the ecosystems back to grasslands," he said.

Ants' role in saving trees is critical with the interest in slowing the accumulation of greenhouse gasses since trees absorb carbon dioxide from the atmosphere, Palmer said.

"These 'ant plants' don't cover just a few hundred acres but are distributed throughout east Africa from southern Sudan all the way over to eastern Zaire and down through the horn of Africa and Tanzania," he said. "So they potentially play a big role in terms of regulating carbon dynamics in these ecosystems."

Aerosols May Drive A Significant Portion Of Arctic Warming

Aerosols can influence climate directly by either reflecting or absorbing the sun's radiation as it moves through the atmosphere. The tiny airborne particles enter the atmosphere from sources such as industrial pollution, volcanoes and residential cooking stoves.

---

Though greenhouse gases are invariably at the center of discussions about global climate change, new NASA research suggests that much of the atmospheric warming observed in the Arctic since 1976 may be due to changes in tiny airborne particles called aerosols.

Emitted by natural and human sources, aerosols can directly influence climate by reflecting or absorbing the sun's radiation. The small particles also affect climate indirectly by seeding clouds and changing cloud properties, such as reflectivity.
A new study, led by climate scientist Drew Shindell of the NASA Goddard Institute for Space Studies, New York, used a coupled ocean-atmosphere model to investigate how sensitive different regional climates are to changes in levels of carbon dioxide, ozone, and aerosols.
The researchers found that the mid and high latitudes are especially responsive to changes in the level of aerosols. Indeed, the model suggests aerosols likely account for 45 percent or more of the warming that has occurred in the Arctic during the last three decades. The results were published in the April issue of Nature Geoscience.
Though there are several varieties of aerosols, previous research has shown that two types -- sulfates and black carbon -- play an especially critical role in regulating climate change. Both are products of human activity.
Sulfates, which come primarily from the burning of coal and oil, scatter incoming solar radiation and have a net cooling effect on climate. Over the past three decades, the United States and European countries have passed a series of laws that have reduced sulfate emissions by 50 percent. While improving air quality and aiding public health, the result has been less atmospheric cooling from sulfates.
At the same time, black carbon emissions have steadily risen, largely because of increasing emissions from Asia. Black carbon -- small, soot-like particles produced by industrial processes and the combustion of diesel and biofuels -- absorb incoming solar radiation and have a strong warming influence on the atmosphere.
In the modeling experiment, Shindell and colleagues compiled detailed, quantitative information about the relative roles of various components of the climate system, such as solar variations, volcanic events, and changes in greenhouse gas levels. They then ran through various scenarios of how temperatures would change as the levels of ozone and aerosols -- including sulfates and black carbon -- varied in different regions of the world. Finally, they teased out the amount of warming that could be attributed to different climate variables. Aerosols loomed large.
The regions of Earth that showed the strongest responses to aerosols in the model are the same regions that have witnessed the greatest real-world temperature increases since 1976. The Arctic region has seen its surface air temperatures increase by 1.5 C (2.7 F) since the mid-1970s. In the Antarctic, where aerosols play less of a role, the surface air temperature has increased about 0.35 C (0.6 F).
That makes sense, Shindell explained, because of the Arctic's proximity to North America and Europe. The two highly industrialized regions have produced most of the world's aerosol emissions over the last century, and some of those aerosols drift northward and collect in the Arctic. Precipitation, which normally flushes aerosols out of the atmosphere, is minimal there, so the particles remain in the air longer and have a stronger impact than in other parts of the world.
Since decreasing amounts of sulfates and increasing amounts of black carbon both encourage warming, temperature increases can be especially rapid. The build-up of aerosols also triggers positive feedback cycles that further accelerate warming as snow and ice cover retreat.
In the Antarctic, in contrast, the impact of sulfates and black carbon is minimized because of the continent's isolation from major population centers and the emissions they produce.
"There's a tendency to think of aerosols as small players, but they're not," said Shindell. "Right now, in the mid-latitudes of the Northern Hemisphere and in the Arctic, the impact of aerosols is just as strong as that of the greenhouse gases."
The growing recognition that aerosols may play a larger climate role can have implications for policymakers.
"We will have very little leverage over climate in the next couple of decades if we're just looking at carbon dioxide," Shindell said. "If we want to try to stop the Arctic summer sea ice from melting completely over the next few decades, we're much better off looking at aerosols and ozone."
Aerosols tend to be quite-short lived, residing in the atmosphere for just a few days or weeks. Greenhouses gases, by contrast, can persist for hundreds of years. Atmospheric chemists theorize that the climate system may be more responsive to changes in aerosol levels over the next few decades than to changes in greenhouse gas levels, which will have the more powerful effect in coming centuries.
"This is an important model study, raising lots of great questions that will need to be investigated with field research," said Loretta Mickley, an atmospheric chemist from Harvard University, Cambridge, Mass. who was not directly involved in the research. Understanding how aerosols behave in the atmosphere is still very much a work-in-progress, she noted, and every model needs to be compared rigorously to real life observations. But the science behind Shindell's results should be taken seriously.
"It appears that aerosols have quite a powerful effect on climate, but there's still a lot more that we need to sort out," said Shindell.
NASA's upcoming Glory satellite is designed to enhance our current aerosol measurement capabilities to help scientists reduce uncertainties about aerosols by measuring the distribution and microphysical properties of the particles.
________________________________________
Adapted from materials provided by NASA/Goddard Space Flight Center.

Sound From Exploding Volcanoes Compared With Jet Engines

Scripps researchers installed an array of microbarometers at Mount St. Helens in November 2004 to collect infrasound near the site

---

New research on infrasound from volcanic eruptions shows an unexpected connection with jet engines. Researchers at Scripps Institution of Oceanography at UC San Diego speeded up the recorded sounds from two volcanoes and uncovered a noise very similar to typical jet engines.

These new research findings provide scientists with a more useful probe of the inner workings of volcanic eruptions. Infrasound is sound that is lower in frequency than 20 cycles per second, below the limit of human hearing.
The study led by Robin Matoza, a graduate student at Scripps Oceanography, will be published in an upcoming issue of the journal Geophysical Research Letters, a publication of the American Geophysical Union (AGU). Matoza measured infrasonic sound from Mount St. Helens in Washington State and Tungurahua volcano in Ecuador, both of which are highly active volcanoes close to large population centers.
"We hypothesized that these very large natural volcanic jets were making very low frequency jet noise," said Matoza, who conducts research in the Scripps Laboratory for Atmospheric Acoustics.
Using 100-meter aperture arrays of microbarometers, similar to weather barometers but sensitive to smaller changes in atmospheric pressure and low-frequency infrasonic microphones, the research team tested the hypothesis, revealing the physics of how the large-amplitude signals from eruptions are produced. Jet noise is generated by the turbulent flow of air out of a jet engine. Matoza and colleagues recorded these very large-amplitude infrasonic signals during the times when ash-laden gas was being ejected from the volcano. The study concluded that these large-scale volcanic jets are producing sound in a similar way to smaller-scale man-made jets.
"We can draw on this area of research to speed up our own study of volcanoes for both basic research interests, to provide a deeper understanding of eruptions, and for practical purposes, to determine which eruptions are likely ash-free and therefore less of a threat and which are loaded with ash," said Michael Hedlin, director of Scripps' Atmospheric Acoustics Lab and a co-author on the paper.
Large-amplitude infrasonic signals from volcanic eruptions are currently used in a prototype real-time warning system that informs the Volcanic Ash Advisory Center (VAAC) when large infrasonic signals have come from erupting volcanoes. Researchers hope this new information can improve hazard mitigation and inform pilots and the aviation industry.
"The more quantitative we can get about how the sound is produced the more information we can provide to the VAAC," said Matoza. "Eventually it could be possible to provide detailed information such as the size or flow rate of the volcanic jet to put into ash-dispersal forecasting models."
The paper's co-authors include D. Fee and M A. Garcés, Infrasound Laboratory at the University of Hawaii at Manoa; J.M. Seiner of the National Center for Physical Acoustics at the University of Mississippi; and P.A. Ramón of Instituto Geofisico, Escuela Politecnica Naional. The research study was funded by a National Science Foundation grant.
________________________________________
Adapted from materials provided by University of California - San Diego.

Ice Storms Devastating To Pecan Orchards

This is the aftermath of an ice storm in a pecan grove near Eufaula, Okla.

---

Ice storms and other severe weather can have devastating impacts on agricultural crops, including perennial tree crops. Major ice storms occur at least once a decade, with truly catastrophic "icing events" recorded once or twice a century within a broad belt extending from eastern Texas through New England. Ice storms can result in overwhelming losses to orchards and expensive cleanup for producers.
Because the long limbs of pecan trees act as levers and increase the likelihood of breakage, pecan orchards and groves are particularly susceptible to damage from tornadoes, hurricanes, and ice storms. Ice damage is typically more severe in pecan orchards than other orchard crops.

Oklahoma has 85,740 acres of pecans on 2,879 farms. Ice storms struck Oklahoma four times from 2000 through 2007. The crippling ice storm in December 2000, which hit the southeast quarter of Oklahoma, extended into parts of Texas, Louisiana, and Arkansas. An estimated 25,000 to 30,000 acres of pecans were damaged in Oklahoma during this storm alone.
Michael W. Smith from the Department of Horticulture and Landscape Architecture at Oklahoma State University, and Charles T. Rohla of the Samuel Roberts Noble Foundation published a research report in the latest issue of HortTechnology that provides pecan producers, government agencies, and insurance companies with important information concerning orchard management and economics following destructive ice storms.
Cleanup of pecan orchards following ice damage presents enormous challenges for producers. Typical damage, cleanup, and recovery from four ice storms that hit the region from 2000 to 2007 were reported in the study. Trees less than 15 feet tall typically had the least damage; trees 15 to 30 feet tall incurred as much or more damage than larger trees and cleanup costs were greater.
The silver lining: pecan trees are resilient. Most trees can survive and eventually return to productivity following loss of most of their crown. But cleanup costs to ice-damaged pecan orchards are high, ranging from $207 to $419 per acre based on the dollar value in 2008. According to the researchers, these costs were consistent among orchards where the owner supervised the labor and had the resources to obtain equipment necessary to prune and remove debris from the orchard. The cleanup costs paid to "custom operators" for renovating orchards following ice storms were significantly more expensive, ranging from $500 to $800 per acre in 2008 for orchards with similar damage levels.
Explaining the outcomes of the research study, Smith stated; "Following damaging weather events, producers seek information concerning effective cleanup procedures, subsequent management, recovery duration, and economic impact. State and Federal agencies and insurance companies seek guidance concerning economic impact and how to assist producers. Our objective was to provide information for producers and others regarding the impact of an ice storm on pecans."
________________________________________
Adapted from materials provided by American Society for Horticultural Science, via EurekAlert!, a service of AAAS.

Hollow Gold Nanospheres Show Promise For Biomedical And Other Applications

Partial view of a gold nanosphere (shown), magnified by a factor of one billion, as seen through an electron microscope. The darker ring shows the "wall" of the nanosphere, while the lighter area to the right of the ring shows the interior region of the shell.

---

A new metal nanostructure developed by researchers at the University of California, Santa Cruz, has already shown promise in cancer therapy studies and could be used for chemical and biological sensors and other applications as well.
The hollow gold nanospheres developed in the laboratory of Jin Zhang, a professor of chemistry and biochemistry at UCSC, have a unique set of properties, including strong, narrow, and tunable absorption of light. Zhang is collaborating with researchers at the University of Texas M. D. Anderson Cancer Center, who have used the new nanostructures to target tumors for photothermal cancer therapy. They reported good results from preclinical studies earlier this year (Clinical Cancer Research, February 1, 2009).

Zhang will describe his lab's work on the hollow gold nanospheres in a talk on Sunday, March 22, at the annual meeting of the American Chemical Society in Salt Lake City.
"What makes this structure special is the combination of the spherical shape, the small size, and the strong absorption in visible and near infrared light," Zhang said. "The absorption is not only strong, it is also narrow and tunable. All of these properties are important for cancer treatment."
Zhang's lab is able to control the synthesis of the hollow gold nanospheres to produce particles with consistent size and optical properties. The hollow particles can be made in sizes ranging from 20 to 70 nanometers in diameter, which is an ideal range for biological applications that require particles to be incorporated into living cells. The optical properties can be tuned by varying the particle size and wall thickness.
In the cancer studies, led by Chun Li of the M. D. Anderson Cancer Center, researchers attached a short peptide to the nanospheres that enabled the particles to bind to tumor cells. After injecting the nanospheres into mice with melanoma, the researchers irradiated the animals' tumors with near-infrared light from a laser, heating the gold nanospheres and selectively killing the cancer cells to which the particles were bound.
Cancer therapy was not the goal, however, when Zhang's lab began working several years ago on the synthesis and characterization of hollow gold nanospheres. Zhang has studied a wide range of metal nanostructures to optimize their properties for surface-enhanced Raman scattering (SERS). SERS is a powerful optical technique that can be used for sensitive detection of biological molecules and other applications.
Adam Schwartzberg, then a graduate student in Zhang's lab at UCSC, initially set out to reproduce work reported by Chinese researchers in 2005. In the process, he perfected the synthesis of the hollow gold nanospheres, then demonstrated and characterized their SERS activity.
"This process is able to produce SERS-active nanoparticles that are significantly smaller than traditional nanoparticle structures used for SERS, providing a sensor element that can be more easily incorporated into cells for localized intracellular measurements," Schwartzberg, now at UC Berkeley, reported in a 2006 paper published in Analytical Chemistry.
The collaboration with Li began when Zhang heard him speak at a conference about using solid nanoparticles for photothermal cancer therapy. Zhang immediately saw the advantages of the hollow gold nanospheres for this technique. Li uses near-infrared light in the procedure because it provides good tissue penetration. But the solid gold nanoparticles he was using do not absorb near-infrared light efficiently. Zhang told Li he could synthesize hollow gold nanospheres that absorb light most efficiently at precisely the wavelength (800 nanometers) emitted by Li's near-infrared laser.
"The heat that kills the cancer cells depends on light absorption by the metal nanoparticles, so more efficient absorption of the light is better," Zhang said. "The hollow gold nanospheres were 50 times more effective than solid gold nanoparticles for light absorption in the near-infrared."
Zhang's group has been exploring other nanostructures that can be synthesized using the same techniques. For example, graduate student Tammy Olson has designed hollow double-nanoshell structures of gold and silver, which show enhanced SERS activities compared to the hollow gold nanospheres.
The ability to tune the optical properties of the hollow nanospheres makes them highly versatile, Zhang said. "It is a unique structure that offers true advantages over other nanostructures, so it has a lot of potential," he said.
________________________________________
Adapted from materials provided by University of California - Santa Cruz, via EurekAlert!, a service of AAAS.

Food Choices Evolve Through Information Overload

Just as information overload leads to people repeatedly choosing what they know, same concept applies equally to hundreds of animal species, too, new research shows

---

Ever been so overwhelmed by a huge restaurant menu that you end up choosing an old favourite instead of trying something new?

Psychologists have long since thought that information overload leads to people repeatedly choosing what they know. Now, new research has shown that the same concept applies equally to hundreds of animal species, too.

Researchers from the University of Leeds have used computer modelling to examine the evolution of specialisation, casting light on why some animal species have evolved to eat one particular type of food. For example some aphids choose to eat garden roses, but not other plants which would offer similar nutritional values.
"This is a major leap forward in our understanding of the way in which animals interact with their environment," says lead researcher Dr Colin Tosh from the University's Faculty of Biological Sciences. "Our computer models show the way in which neural networks operate in different environments. They have made it possible for us to see how different species make decisions, based on what's happening – or in this case, which foods are available - around them."
Despite the prevalence of specialisation in the animal kingdom, very little is known about why it occurs. The work conducted at Leeds has provided strong evidence in support of the 'neural limitations' hypothesis put forward by academics in the 1990s. This hypothesis, derived from human psychology, is based on the concept of information overload.
"There are several hypotheses to explain specialisation: one suggests that animals adapt to eat certain foods and this prevents them from eating other types of food," says Dr Tosh.
"For example, cows have evolved flat teeth which allow them to chew grass but they are unable to efficiently process meat. However, the problem with these hypotheses is that they don't apply across the board. Some species – such as many plant eating insects – have evolved to specialise even though there are many other available foods they could eat perfectly well."
This is the first study to provide a realistic representation of neural information processing in animals and how these interact with their environment. The research team believe that it could also have major implications for predicting the effects of environmental change.
"A good example of a struggling specialist is the giant panda, which relies on high mountain bamboo," says Dr Tosh. "In understanding how neural processes work, we may be able to gain an insight into how future environmental conditions – such as the dying out of particular types of plants - may affect a range of different animal species that utilise them for food."
This research was funded by the Natural Environment Research Council in the UK.
________________________________________
Adapted from materials provided by University of Leeds, viaEurekAlert!, a service of AAAS.

Genetic Study Finds Treasure Trove Of New Lizards

New species of gecko that was once thought to be Diplodactylus tessellatus.

---

University of Adelaide research has discovered that there are many more species of Australian lizards than previously thought, raising new questions about conservation and management of Australia's native reptiles.
PhD student Paul Oliver, from the University's School of Earth and Environmental Sciences, has done a detailed genetic study of the Australian gecko genus Diplodactylus and found more than twice the recognised number of gecko species, from 13 species to 29. This study was done in collaboration with the South Australian Museum and Western Australian Museum.

"Many of these species are externally very similar, leading to previous severe underestimation of true species diversity," says Mr Oliver.
"One of the major problems for biodiversity conservation and management is that many species remain undocumented.
"This problem is widely acknowledged to be dire among invertebrates and in developing countries.
"But in this group of vertebrates in a developed nation, which we thought we knew reasonably well, we found more than half the species were unrecognised."
Mr Oliver says this has great significance for conservation. For instance, what was thought to be a single very widespread species of gecko has turned out to be eight or nine separate species with much narrower, more restricted habitats and possibly much more vulnerable to environmental change, he says.
"This completely changes how we look at conservation management of these species," he says.
"Even at just the basic inventory level, this shows that there is a lot of work still to be done. Vertebrate taxonomy clearly remains far from complete with many species still to be discovered. This will require detailed genetic and morphological work, using integrated data from multiple sources. It will require considerable effort and expense but with potentially rich returns."
The research was supported by grants from the Australia Pacific Science Foundation and the Australian Biological Resources Study.
________________________________________
Adapted from materials provided by University of Adelaide.

Teenage Boys Who Eat Fish At Least Once A Week Achieve Higher Intelligence Scores

New research has found that 15-year-old males who ate fish at least once a week displayed higher cognitive skills at the age of 18 than those who it ate it less frequently.

---

Fifteen-year-old males who ate fish at least once a week displayed higher cognitive skills at the age of 18 than those who it ate it less frequently, according to a study of nearly 4,000 teenagers published in the March issue of Acta Paediatrica.
Eating fish once a week was enough to increase combined, verbal and visuospatial intelligence scores by an average of six per cent, while eating fish more than once a week increased them by just under 11 per cent.
Swedish researchers compared the responses of 3,972 males who took part in the survey with the cognitive scores recorded in their Swedish Military Conscription records three years later.

"We found a clear link between frequent fish consumption and higher scores when the teenagers ate fish at least once a week" says Professor Kjell Torén from the Sahlgrenska Academy at the University of Gothenburg, one of the senior scientists involved in the study. "When they ate fish more than once a week the improvement almost doubled.
"These findings are significant because the study was carried out between the ages of 15 and 18 when educational achievements can help to shape the rest of a young man's life."
The research team found that:

• • 58 per cent of the boys who took part in the study ate fish at least once a week and a further 20 per cent ate fish more than once a week.
• • When male teenagers ate fish more than once a week their combined intelligence scores were on average 12 per cent higher than those who ate fish less than once a week. Teenagers who ate fish once a week scored seven per cent higher.
• • The verbal intelligence scores for teenagers who ate fish more than once a week were on average nine per cent higher than those who ate fish less than once a week. Those who ate fish once a week scored four per cent higher.
• • The same pattern was seen in the visuospatial intelligence scores, with teenagers who ate fish more than once a week scoring on average 11 per cent higher than those who ate fish less than once a week. Those who ate fish once a week scored seven per cent higher.

"A number of studies have already shown that fish can help neurodevelopment in infants, reduce the risk of impaired cognitive function from middle age onwards and benefit babies born to women who ate fish during pregnancy" says Professor Torén.

"However we believe that this is the first large-scale study to explore the effect on adolescents."
The exact mechanism that links fish consumption to improved cognitive performance is still not clear.
"The most widely held theory is that it is the long-chain polyunsaturated fatty acids found in fish that have positive effects on cognitive performance" explains Professor Torén.
"Fish contains both omega-3 and omega-6 fatty acids which are known to accumulate in the brain when the foetus is developing. Other theories have been put forward that highlight their vascular and anti-inflammatory properties and their role in suppressing cytokines, chemicals that can affect the immune system."
In order to isolate the effect of fish consumption on the study subjects, the research team looked at a wide range of variables, including ethnicity, where they lived, their parents' educational level, the teenagers' well-being, how frequently they exercised and their weight.
"Having looked very carefully at the wide range of variables explored by this study it was very clear that there was a significant association between regular fish consumption at 15 and improved cognitive performance at 18" concludes lead author Dr Maria Aberg from the Centre for Brain Repair and Rehabilitation at the University of Gothenburg.
"We also found the same association between fish and intelligence in the teenagers regardless of their parents' level of education."
The researchers are now keen to carry out further research to see if the kind of fish consumed - for example lean fish in fish fingers or fatty fish such as salmon - makes any difference to the results.
"But for the time being it appears that including fish in a diet can make a valuable contribution to cognitive performance in male teenagers" says Dr Aberg.
________________________________________
Adapted from materials provided by Wiley-Blackwell, viaEurekAlert!, a service of AAAS.

Gray Wolves No Longer To Be Listed As Threatened And Endangered Species In Western Great Lakes, Portion Of Northern Rockies

Two gray wolves.

---

Secretary of the Interior Ken Salazar has affirmed on March 6 the decision by the U.S. Fish and Wildlife Service to remove gray wolves from the list of threatened and endangered species in the western Great Lakes and the northern Rocky Mountain states of Idaho and Montana and parts of Washington, Oregon and Utah. Wolves will remain a protected species in Wyoming.
“The recovery of the gray wolf throughout significant portions of its historic range is one of the great success stories of the Endangered Species Act,” Salazar said. “When it was listed as endangered in 1974, the wolf had almost disappeared from the continental United States. Today, we have more than 5,500 wolves, including more than 1,600 in the Rockies.”
“The successful recovery of this species is a stunning example of how the Act can work to keep imperiled animals from sliding into extinction,” he said. “The recovery of the wolf has not been the work of the federal government alone. It has been a long and active partnership including states, tribes, landowners, academic researchers, sportsmen and other conservation groups, the Canadian government and many other partners.”

The Fish and Wildlife Service originally announced the decision to delist the wolf in January, but the new administration decided to review the decision as part of an overall regulatory review when it came into office. The Service will now send the delisting regulation to the Federal Register for publication.
The Service decided to delist the wolf in Idaho and Montana because they have approved state wolf management plans in place that will ensure the conservation of the species in the future.
At the same time, the Service determined wolves in Wyoming would still be listed under the Act because Wyoming’s current state law and wolf management plan are not sufficient to conserve its portion of northern Rocky Mountain wolf population.
Gray wolves were previously listed as endangered in the lower 48 states, except in Minnesota where they were listed as threatened. The Service oversees three separate recovery programs for the gray wolf; each has its own recovery plan and recovery goals based on the unique characteristics of wolf populations in each geographic area.
Wolves in other parts of the 48 states, including the Southwest wolf population, remain endangered and are not affected by the actions taken today.

About Northern Rocky Mountain Wolves
The northern Rocky Mountain Distinct Population Segment includes all of Montana, Idaho and Wyoming, the eastern one-third of Washington and Oregon, and a small part of north-central Utah. The minimum recovery goal for wolves in the northern Rocky Mountains is at least 30 breeding pairs and at least 300 wolves for at least three consecutive years, a goal that was attained in 2002 and has been exceeded every year since. There are currently about 95 breeding pairs and 1,600 wolves in Montana, Idaho, and Wyoming.
The Service believes that with approved state management plans in place in Montana and Idaho, all threats to the wolf population will be sufficiently reduced or eliminated in those states. Montana and Idaho will always manage for more than 15 breeding pairs and 150 wolves per state and their target population level is about 400 wolves in Montana and 500 in Idaho.
As a result of a Montana United States District Court decision on July 18, 2008, the Service reexamined Wyoming law, its management plans and implementing regulations. While the Service has approved wolf management plans in Montana and Idaho, it has determined that Wyoming’s state law and wolf management plan are not sufficient to conserve Wyoming’s portion of a recovered northern Rocky Mountain wolf population. Therefore, even though Wyoming is included in the northern Rocky Mountain District Population Segment, the subpopulation of gray wolves in Wyoming is not being removed from protection of the Endangered Species Act.
Continued management under the Endangered Species Act by the Service will ensure that wolves in Wyoming will be conserved. Acting U.S. Fish and Wildlife Service Director Rowan Gould said the Service will continue to work with the State of Wyoming in developing its state regulatory framework so that the state can continue to maintain its share of a recovered northern Rocky Mountain population. Once adequate state regulatory mechanisms are in place, the Service could propose removing the Act’s protections for wolves in Wyoming. National parks and the Wind River Reservation in Wyoming already have adequate regulatory mechanisms in place to conserve wolves. However, at this time, wolves will remain protected as a nonessential, experimental population under the ESA throughout the state, including within the boundaries of the Wind River Reservation and national park and refuge units.

Western Great Lakes Region
The Service’s delisting of the gray wolf also applies to gray wolves in the Western Great Lakes Distinct Population Segment. As the result of another legal ruling from the Washington D.C. United States District Court on September 29, 2008, the Service reexamined its legal authorization to simultaneously identify and delist a population of wolves in the western Great Lakes. The Service today reissued the delisting decision in order to comply with the Court’s concerns.
The area included in the DPS boundary includes the states of Minnesota, Wisconsin and Michigan as well as parts of North Dakota, South Dakota, Iowa, Illinois, Indiana and Ohio. The DPS includes all the areas currently occupied by wolf packs in Minnesota, Michigan, and Wisconsin, as well as nearby areas in these states in which wolf packs may become established in the future. The DPS also includes surrounding areas into which wolves may disperse but are not likely to establish packs.
Rebounding from a few hundred wolves in Minnesota in the 1970s when listed as endangered, the region’s gray wolf population now numbers about 4,000 and occupies large portions of Wisconsin, Michigan and Minnesota. Wolf numbers in the three states have exceeded the numerical recovery criteria established in the species’ recovery plan for several years. In Minnesota, the population is estimated at 2,922. The estimated wolf population in Wisconsin is a minimum of 537, and about 520 wolves are believed to inhabit Michigan’s Upper Peninsula.
The Michigan, Minnesota, and Wisconsin Departments of Natural Resources have developed plans to guide wolf management actions in the future. The Service has determined that these plans establish a sufficient basis for long-term wolf management. They address issues such as protective regulations, control of problem animals, possible hunting and trapping seasons, and the long-term health of the wolf population, and will be governed by the appropriate state or tribe.
The Service will monitor the delisted wolf populations for a minimum of five years to ensure that they continue to sustain their recovery. At the end of the monitoring period, the Service will decide if relisting, continued monitoring or ending Service monitoring is appropriate.
________________________________________
Adapted from materials provided by U.S. Department of the Interior.

Inactivity Of Proteins Behind Longer Shelf Life When Freezing

Frozen biological material, for example food, can be kept for a long time without perishing. A new study is close to providing answers as to why.

---

Frozen biological material, for example food, can be kept for a long time without perishing. A study by researchers at the University of Gothenburg, Sweden, is close to providing answers as to why.
A cell's proteins are programmed to carry out various biological functions. The protein's level of activity and its ability to successfully carry out these functions is dependent on the amount of water by which it is surrounded. For example, dry proteins are completely inactive. A critical amount of water is required in order for the function to get going, after which point the protein's level of activity increases concurrently with an increase in the amount of water. Proteins achieve full biological activity when the surrounding water has approximately the same weight as the protein.

Researchers at the University of Gothenburg and Chalmers University of Technology have together with a group of American researchers used advanced experimental techniques to study how movements in the water that surrounds the protein cause movements in the protein itself. The study, which is being published in the journal PNAS, indicates that the dynamics in the surrounding water have a direct effect on the protein's dynamics, which, in turn, should affect the activity.
The results explain, for example, why biological material such as foodstuffs or research material can be stored at low temperatures for a long period of time without perishing.
"When the global movements in the surrounding water freeze, then significant movements within the protein also come to a stop. This results in the protein being preserved in a state of minimum energy and biological activity comes to a stop," says researcher Helén Jansson at the Swedish NMR Centre, University of Gothenburg, Sweden.
________________________________________
Adapted from materials provided by University of Gothenburg.

40-year Mystery Revisited: Newtonian System Mimics 'Baldness' Of Rotating Black Holes

Clifford Will hopes to learn more about how small black holes orbit around rotating massive black holes in general relativity, where the relativistic Carter constant plays a key role.

---

The rotating black hole has been described as one of nature's most perfect objects. As described by the Kerr solution of Einstein's gravitational field equations, its spacetime geometry is completely characterized by only two numbers — mass and spin — and is sometimes described by the aphorism "black holes have no hair.''
A particle orbiting a rotating black hole always conserves its energy and angular momentum, but otherwise traces a complicated twisting rosette pattern with no discernible regularity.
But in 1968, theoretical physicist and cosmologist Brandon Carter showed that the particle's wild gyrations nevertheless hold another variable fixed, which was named the "Carter constant.'' The true meaning of Carter's constant still remains somewhat mysterious 40 years after its discovery.

Now Clifford M. Will, Ph.D., the James S. McDonnell Professor of Physics in Arts & Sciences at Washington University in St. Louis, has shown that, even in Newton's theory of gravitation, arrangements of masses exist whose gravitational field also admits a Carter-like constant of motion, in addition to energy and angular momentum.
What's more, the deviation of the field's shape from being spherical is determined by a set of equations that are identical to those for Kerr black holes.
In his article "Carter-like Constants of the Motion in Newtonian Gravity and Electrodynamics" in the Feb. 12 issue of Physical Review Letters, Will points out that one Newtonian system that exhibits this property is surprisingly simple: two equal point masses at rest separated by a fixed distance.
"I was completely stunned when I saw that the Newtonian condition for a Carter constant was identical to the condition imposed by the black hole no-hair theorems," said Will. "Do I know why this happens? So far, not a clue.
"But what I really hope is that insights gained about this strange constant in the simpler Newtonian context will teach us something about how small black holes orbit around rotating massive black holes in general relativity, where the relativistic Carter constant plays a key role."
This will have implications for gravitational-wave astronomy, he says, because the signal from such events may be detectable by the advanced LIGO-VIRGO-GEO network of ground-based laser interferometric detectors or by the proposed space-based LISA (Laser Interferometer Space Antenna).
Will, who is also a visiting associate at the Institute of Astrophysics in Paris, is a theoretical physicist whose research interests encompass the observational and astrophysical implications of Einstein's general theory of relativity, including gravitational radiation, black holes, cosmology, the physics of curved spacetime and the interpretation of experimental tests of general relativity.
Will's "Was Einstein Right?" (1986) won the American Institute of Physics Science Writing Award. His "Theory and Experiment in Gravitational Physics" (1981) is considered the bible of the field.
His research was supported in part by the National Science Foundation, the National Aeronautics and Space Administration and the Centre National de la Recherche Scientifique, Programme Internationale de la Cooperation Scientifique.
________________________________________
Adapted from materials provided by Washington University in St. Louis.

Antibiotic Resistance: Rising Concern In Marine Ecosystems

Volunteers participate in research conducted by the University of Miami's Leonard M. Miller School of Medicine and Rosenstiel School of Marine and Atmospheric Science. Preliminary results unveiled at the 2009 AAAS Annual Meeting show that swimmers using subtropical public ocean beaches increase their risk for exposure to staph organisms, and may increase their risk for potential staph infections. Results also show the potentially virulent variety of antibiotic resistant staph, MRSA, makes up less than three per cent of staph from the beach waters sampled during the study.

---

A team of scientists, speaking February 13 at the annual meeting of the American Association for the Advancement of Science, called for new awareness of the potential for antibiotic-resistant illnesses from the marine environment, and pointed to the marine realm as a source for possible cures of those threats.
The group stated that newly completed studies of ocean beach users point to an increasing risk of staph infections, and that current treatments for seafood poisoning may be less effective due to higher than expected antibiotic resistance. The group also asserts that new research has identified sponge and coral-derived chemicals with the potential for breaking down antibiotic resistant compounds and that could lead to new personalized medical treatments.

"While the marine environment can indeed be hostile to humans, it may also provide new resources to help reduce our risks from illnesses such as those caused by water borne staph or seafood poisoning," stated Paul Sandifer, Ph.D., former member of the U.S. Commission on Ocean Policy, chief scientist of NOAA's Oceans and Human Health Initiative, and co-organizer of the symposium.
Carolyn Sotka, also with the NOAA Oceans and Human Health Initiative and lead organizer of the session, stated "It is critically important that we continue research on the complex interactions between the condition of our oceans and human health. Without doubt, this research will develop new understandings of ocean health risks and perhaps more importantly crucial discoveries that will lead to new solutions to looming public health problems."

Coral, Sponges Point To Personalized Medicine Potential
"We've found significant new tools to fight the antibiotic resistance war," says NOAA research scientist Peter Moeller, Ph.D., in describing the identification of new compounds derived from a sea sponge and corals.
"The first hit originates with new compounds that remove the shield bacteria utilize to protect themselves from antibiotics. The second hit is the discovery of novel antibiotics derived from marine organisms such as corals, sponges and marine microbes that fight even some of the worst infectious bacterial strains. With the variety of chemicals we find in the sea and their highly specific activities, medicines in the near future can be customized to individuals' needs, rather than relying on broad spectrum antibiotics."
The research team, a collaboration between scientists at NOAA's Hollings Marine Laboratory in Charleston, S.C., the Medical University of South Carolina and researchers at North Carolina State University in Raleigh, N.C., noticed a sponge that seemed to thrive despite being located in the midst of a dying coral reef. After extraction, testing showed that one of the isolated chemicals, algeliferin, breaks down a biofilm barrier that bacteria use to protect themselves from threats including antibiotics. The same chemical can also disrupt or inhibit formation of biofilm on a variety of bacteria previously resistant to antibiotics which could lead to both palliative and curative response treatment depending on the problem being addressed.
"This could lead to a new class of helper drugs and result in a rebirth for antibiotics no longer thought effective," notes Moeller. "Its potential application to prevent biofilm build-up in stents, intravenous lines and other medical uses is incredible."
The compound is currently being tested for a variety of medical uses and has gone through a second round of sophisticated toxicity screening and thus far shows no toxic effects.

Staph: A Beach Going Concern
Research, funded by multiple agencies and conducted by the University of Miami's Rosenstiel School of Marine and Atmospheric Sciences and the Leonard M. Miller School of Medicine, found that swimmers using public ocean beaches increase their risk for exposure to staph organisms, and they may increase their risk for potential staph infections once they enter the water.
"Our study found that if you swim in subtropical marine waters, you have a significant chance , approximately 37 percent, of being exposed to staph — either yours or possibly that from someone else in the water with you," said Dr. Lisa Plano, a pediatrician and microbiologist with the Miller School of Medicine. Plano collaborated in the first large epidemiologic survey of beach users in recreational marine waters without a sewage source of pollution. "This exposure might lead to colonization or infection by water-borne bacteria which are shed from every person who enters the water. People who have open wounds or are immune-compromised are at greatest risk of infection."
The Miami research team does not advise avoiding beaches, but recommends that beach-goers take precautions to reduce risk by showering thoroughly before entering the water and after getting out. They also point out that while antibiotic resistant staph, commonly known as MRSA, has been increasingly found in diverse environments, including the marine environment, less than three percent of staph isolated from beach waters in their study was of the potentially virulent MRSA variety. More research is needed to understand how long staph (including MRSA) can live in coastal waters, and human uptake and infection rates associated with beach exposures.

Antibiotic Resistance in Seafood-borne Pathogens Increasing
Researchers at the Bigelow Laboratory for Ocean Science in West Boothbay Harbor, Maine, report that the frequency of antibiotic resistance in vibrio bacteria was significantly higher than expected. These findings suggest that the current treatment of vibirio infections should be re-examined, since these microbes are the leading cause of seafood-borne illness and death in the United States. The severity of these infections makes antibiotic resistance in vibrios a critical public health concern.
Naturally-occurring resistance to antibiotics among Vibrios may undermine the effectiveness of antibiotic treatment, but as yet this has not been extensively studied. Furthermore, antibiotics and other toxicants discharged into the waste stream by humans may increase the frequency of antibiotic-resistant Vibrio strains in contaminated coastal environments.
"We found resistance to all major classes of antibiotics routinely used to treat Vibrio infections, including aminoglycosides, tetracyclines, and cephalosporins," stated Bigelow's Ramunas Stepanauskas, Ph.D. "In contrast, we found that Vibrios were highly susceptible to carbapenems and new-generation fluoroquinolones, such as Imipenem and Ciprofloxacin. This information may be used to design better strategies to treat Vibrio infections."
________________________________________
Adapted from materials provided by National Oceanic And Atmospheric Administration, via EurekAlert!, a service of AAAS.

Carotenoids Are Cornerstone Of Bird's Vitality

Arizona house finches.

---

"What you see is what you get" often is the mantra in the highly competitive life of birds, as they use brilliant displays of color to woo females for mating. Now researchers are finding that carotenoids -- the compounds responsible for amping up red, orange, and yellow colors of birds -- also may play a role in color perception and in a bird's ability to reproduce, making it a cornerstone in birds' vitality.
These are among the findings presented by Kevin McGraw, an Arizona State University assistant professor in the School of Life Sciences, at the American Association for the Advancement of Science annual meeting in Chicago. McGraw presented his findings Feb. 13 during a special session on evolutionary biology, called "Beyond the beagle: evolutionary approaches to the study of social behavior."

"Carotenoids play fascinating and multifaceted roles in the lives of animals," McGraw said. "For years, we have known that, as antioxidants, they boost human health and, as colorants, make birds colorful and sexually attractive. Now, we are blending as well as expanding these paradigms and studying how consumption of carotenoids can improve or 'tune' their color vision, promote the health of offspring as they develop in the egg, and possibly improve male sperm quality."
McGraw presented his findings in the paper, "Carotenoids as narcissistic agents of color evolution: A bird's eye view." McGraw, a biochemical ecologist and evolutionary biologist who has studied diet, coloration and physiology in birds, led the work that included post-doctoral researcher Melissah Rowe and Ph.D. student, Matthew Toomey.
Researchers have long thought that carotenoids – responsible for the orange color of carrots and the red of lobster – play an important role in the evolutionary lives of birds by providing them with health benefits and vibrant colors. Because these pigments are limited in the diet and for physiological purposes, their use in coloration provides "honest, accurate information" about the bird's overall quality as a mate. McGraw's new work expands the scope of research on carotenoids to include many other behavioral and physiological benefits they may provide, including superior color perception and gamete formation.
"Like in humans, carotenoids are also deposited in the retina, where they may protect the eye from photodamage by the Sun. There also is evidence that they can shape how well colors can be discriminated visually," McGraw explained. "Ultimately, we envision a model where the more carotenoids you eat, the better you can see color, the better mates you choose, and the redder the foods you choose, thus giving you even more carotenoids for health, attractiveness and vision. In a sense it is a carotenoid circle of life."
McGraw and colleagues are studying a native Arizona desert songbird species (the house finch) as well as two widespread ducks (mallard and northern pintail) to better understand how carotenoids are allocated and prioritized among all of these diverse fitness (survival and reproduction) functions.
"For decades, poultry scientists and human egg-consumers have been interested in the carotenoids that chicken hens put into their yellow egg yolks. We now know that these nutrients aid in the health, growth, and perhaps eventual coloration and mate quality of their offspring," McGraw said. Carotenoids may also affect the male gametes, sperm.
"Testes and seminal fluid can be enriched with carotenoids, preventing sperm cells from oxidative damage and resulting in greater fertilization ability of males," McGraw explained. "If this is the case, carotenoids really could enhance nearly every life-stage and aspect of survival and reproduction in birds."
"We are proposing a positive fitness feedback loop for these 'self-loving molecules,' given how high carotenoid accumulation can improve one's state and one's interest in selecting carotenoid richness in mates and food. This provides a window into how major sexual selection models, such as sensory biases and assortative mating, may be explained by a common, nutritional and narcissistic currency," McGraw added.
________________________________________
Adapted from materials provided by Arizona State University, via EurekAlert!, a service of AAAS.